People Naturally Resist Making Changes in Their Lives Essay

There is a sentence meaning: â€Å"Rivers have their smooth areas as well as their rough regions, and the life of human beings go up at this time and go down at another time†. Therefore, people have to renew themselves, keep learning new things to overcome challenges. People, however, naturally refuse to make changes in their lives. This leads them to be unable to adapt to new environments. Growing up, studying, making friends, and getting jobs†¦ are the important issues of everyone’s life. Every issue is put into different situations which have various difficulties and require some specific skills. For instance, the environment between high school and university is not the same. In high school, teachers pay full attention to you, make sure that you DEEPLY understand deeply subjects, do homework, and learn lessons by heart. On the contrary, you have to motivate yourself to study. That is not THE teachers’ duty. If you don’t make changes in your study methods, and still wait for help from the teachers, your study will decrease dramatically and you surely get bad results. Making changes is difficult but IT doesn’t mean that we can’t do it. In my opinion, there are some steps to help you to get into a new habit. First step is to change your mind. You should carefully consider advantages and drawbacks between new things and old ones. For example, sending mails through (I)nternet is quicker, cheaper, and more convenient than doing them by hand. Next, you should learn it a little everyday, ask the help of your family and your friends. Finally, you will be an expert. In conclusion, the world’s today doesn’t stand at the same point, but always changes every minute. If you don’t update, study new technologies, and skills continuously, you will SOON be out of touch with the world. Human’s life always changes day by day. Therefore, it sets requirements for us to change toward new conditions of living. However, many analyses have pointed out that most people naturally resist making change in their lives. This nature respond actually leads to many problems. On the one hand, many people consider avoiding changes as a way to avoid troubles. For example, a worker chooses to keep using the old machine instead of new one just because he or she does not want to learn how to use the new. They feel better when just working in familiar condition. This natural though is understandable because safety is one of the most important needs for everyone. On the other hand, changeable people claim that making changes is necessary to reach higher success in life. A successful business man said that if we just do what we have done, we just get what we have got. This statement partly implies important role of changes in human’s life. When we avoid making changes, we also by ourselves ignore all opportunities to go further in career. And in a rapid development society, this means that we become backward people. More seriously, what if young generation become passive, and is never ready to change? This will create a weak and low quality labor force in the near future. Of course, a weak labor force cannot help develop country as we desire. That is because they avoid changes, avoid new modern technology or other things, and so they cannot catch with rapid development of the world.

Criminology and Terrorism

J. Paul BatraProfessor Barnes Research Paper Final due 4/19/10 April 1, 2010 Terrorism Introduction Terrorism is defined loosely based on the Latin word Terre, which means to frighten. To be considered an act of terrorism, which is a political crime, an act must carry with it the intent to disrupt and the change the government and should not be merely a common-law crime committed for greed or egotism. The discipline of economics has many concepts that are relevant to an understanding of terrorism — supply and demand — costs and benefits, etc. Fully-developed economic or econometric models of terrorism are quite rare, however, and often involve such things as â€Å"psychic† costs and benefits (Nyatepe-Coo 2004). More down-to-earth economic theories can be found in the literature on deterrence. Rational choice theory, in particular, has found a place in criminology, and holds that people will engage in crime after weighing the costs and benefits of their actions to arrive at a rational choice about motivation after perceiving that the chances of gain outweigh any possible punishment or loss. The second theory that can explain the motivation behind terrorism is the relative deprivation hypothesis which is the idea that as a person goes about choosing their values and interests, they compare what they have and don't have, as well as what they want or don't want, with real or imaginary others. The person then usually perceives a discrepancy between what is possible for them and what is possible for others, and reacts to it with anger or an inflamed sense of injustice. We should be advised that debates exist within criminology regarding relative deprivation and terrorism, on the one hand, with the anomie or strain tradition which finds causal influence in such objectivist factors as Gross Domestic Product, and on the other hand, with the left realist tradition which finds causal influence in subjective experiences of deprivation or discomfort Crime Characteristics of Terrorism: Terrorism is not new, and even though it has been used since the beginning of recorded history it can be relatively hard to define. Terrorism has been described variously as both a tactic and strategy; a crime and a holy duty; a justified reaction to oppression and an inexcusable abomination. Obviously, a lot depends on whose point of view is being represented. Terrorism has often been an effective tactic for the weaker side in a conflict. As an asymmetric form of conflict, it confers coercive power with many of the advantages of military force at a fraction of the cost. Due to the secretive nature and small size of terrorist organizations, they often offer opponents no clear organization to defend against or to deter. The United States Department of Defense defines terrorism as â€Å"the calculated use of unlawful violence or threat of unlawful violence to inculcate fear; intended to coerce or to intimidate governments or societies in the pursuit of goals that are generally political, religious, or ideological. † Within this definition, there are three key elements—violence, fear, and intimidation—and each element produce terror in its victims. The FBI uses this: â€Å"Terrorism is the unlawful use of force and violence against persons or property to intimidate or coerce a government, the civilian population, or any segment thereof, in furtherance of political or social objectives. † The U. S. Department of State defines â€Å"terrorism† to be â€Å"premeditated politically-motivated violence perpetrated against non-combatant targets by sub-national groups or clandestine agents, usually intended to influence an audience. (International Terrorism and Security Research). Technological terrorism is defined as actions directed against infrastructure elements critically important for national security or committed with the use of especially hazardous technologies, technical means, and materials. In considering technological terrorism scenarios, the primary impact factors of such terrorist acts initiate secondary catastrophic processes with a significantly higher (tens and hundreds of times) level of secondary impact factors that affect the targets of the ttack, their personnel, the public, and the environment. (Nikolai A. Makhutov, Vitaly P. Petrov, and Dmitry O. Reznikov, Russian Academy of Sciences Institute of Machine Sciences )Although what we don't know about the psychology of terrorism is more than what we do know, there have been several promising attempts to merge or combine psychology with sociology (and criminal justice) into what might be called terrorist profiling (Russell and Miller 1977; Bell 1982; Galvin 1983; Strentz 1988; Hudson 1999). This line of inquiry actually has a long history, and includes what rare studies exist of female terrorists. The earliest study (Russell and Miller 1977) found that the following people tend to join terrorist organizations: †¢ 22-25 years of age †¢ 80% male, with women in support roles †¢ 75-80% single †¢ 66% middle or upper class background †¢ 66% some college or graduate work †¢ 42% previous participation in working class advocacy groups †¢ 17% unemployed †¢ 18% strong religious beliefs IBLIOGRAPHY NOTE: Characteristics of Technological Terrorism Scenarios and Impact Factors* http://www. nap. edu/openbook. php? record_id=12490=53 The Economics theory of Rational Choice Theory as a theory of terrorism contends that these criminals usually come to believe their actions will be beneficial — to themselves, their community, or society — AND they must come to see that crime pays, or is at least a risk-free way to better their situatio n. Perhaps the most well-known version of this idea in criminology is routine activities theory (Cohen and Felson 1979), which postulates that three conditions must be present in order for a crime to occur: (1) suitable targets or victims who put themselves at risk; (2) the absence of capable guardians or police presence; and (3) motivated offenders or a pool of the unemployed and alienated. Other rational choice theories exist which delve further into models of decision making. In the few models of collective iolence that have found their way into criminology, the Olson hypothesis (source unknown) suggests that participants in revolutionary violence predicate their behavior on a rational cost-benefit calculus to pursue the best course of action given the social circumstances. Bibligraphy note: (THEORIES AND CAUSES OF TERRORISM) http://www. apsu. edu/oconnort/3400/3400lect02. htm) .   As far as we know, most terrorists feel that they are doing nothing wrong when they kill and injure p eople. They seem to share a feature of the psychological condition known as antisocial personality disorder or psychopathic personality disorder, which is reflected by an absence of empathy for the suffering of others. However, they do not appear unstable or mentally ill for this. A common feature is a type of thinking such as â€Å"I am good and right. You are bad and wrong. †Ã‚   It is a very polarized thinking which allows them to distance themselves from opponents and makes it easier for them to kill people. It is not the same kind of simplistic thinking one would expect from someone with low intelligence or moral development. Most terrorists are of above average intelligence and have sophisticated ethical and moral development. A closed-minded certainty is a common feature of terrorist thinking. (Merari 1990). Relative Deprivation occurs where individuals or groups subjectively perceive themselves as unfairly disadvantaged over others perceived as having similar attributes and deserving similar rewards (their reference groups). It is in contrast with absolute deprivation, where biological health is impaired or where relative levels of wealth are compared based on objective differences – although it is often confused with the latter. Subjective experiences of deprivation are essential and, indeed, relative deprivation is more likely when the differences between two groups narrows so that comparisons can be easily made than where there are caste-like differences. The discontent arising from relative deprivation has been used to explain radical politics (whether of the left or the right), messianic religions, the rise of social movements, industrial disputes and the whole plethora of crime and deviance. The usual distinction made is that religious fervour or demand for political change are a collective response to relative deprivation whereas crime is an individualistic response. But this is certainly not true of many crimes – for example, smuggling, poaching or terrorism – which have a collective nature and a communal base and does not even allow for gang delinquency which is clearly a collective response. The connection is, therefore, largely under-theorized – a reflection of the separate development of the concept within the seemingly discrete disciplines of sociology of religion, political sociology and criminology. The use of relative deprivation in criminology is often conflated with Merton's anomie theory of crime and deviance and its development by Cloward and Ohlin, and there are discernible, although largely unexplored, parallels. Anomie theory involves a disparity between culturally induced aspirations (eg success in terms of the American Dream) and the opportunities to realise them. The parallel is clear: this is a subjective process wherein discontent is transmuted into crime. Furthermore, Merton in his classic 1938 article, ‘Social Structure and Anomie', clearly understands the relative nature of discontent explicitly criticising theories which link absolute deprivation to crime by pointing to poor countries with low crime rates in contrast to the wealthy United States with a comparatively high rate. But there are clear differences, in particular Mertonian anomie involves an inability to realise culturally induced notions of success. It does not involve comparisons between groups but individuals measuring themselves against a general goal. The fact that Merton, the major theorist of reference groups, did not fuse this with his theory of anomie is, as Runciman notes, very strange but probably reflects the particular American concern with ‘winners' and ‘losers' and the individualism of that culture. The empirical implications of this difference in emphasis are, however, significant: anomie theory would naturally predict the vast majority of crime to occur at the bottom of society amongst the ‘losers' but relative deprivation theory does not necessarily have this overwhelming class focus. For discontent can be felt anywhere in the class structure where people perceive their rewards as unfair compared to those with similar attributes. Thus crime would be more widespread although it would be conceded that discontent would be greatest amongst the socially excluded. The future integration of anomie and relative deprivation theory offers great promise in that relative deprivation offers a much more widespread notion of discontent and its emphasis on subjectivity insures against the tendency within anomie theory of merely measuring objective differences in equality (so called ‘strain' theory) whereas anomie theory, on its part, offers a wider structural perspective in terms of the crucial role of differential opportunity structures and firmly locates the dynamic of deprivation within capitalist society as a whole. To be completed: Application: Conclusion: Bibliography

Market and Society Essay Example | Topics and Well Written Essays - 1000 words

Market and Society - Essay Example As such, there are various forms of capitalism, which includes state capitalism, welfare capitalism and laissez-faire (Bowles 2007, p. 41). Through the historical accounts, it is said that capitalism came into existence following the fall of feudal system and this explains its dominance in the western world in the earlier times, and now. Capitalism in this regard has been applied over a period in different geographical areas that embrace different cultures with varied political approaches (Ingham 2008, p. 34). Work in the Category of Economy in the Capitalist World In this case, work also referred to as labor, should be of significance purpose to the economy; it should be able to have a positive effect on the economic status of the society. This also explains why in the capitalist countries, there have been many endeavors to manage the labor so that the efficiency of their input can be maximized in the total output that is achieved. As explained above, capitalism is driven by the amo unt of profit, which interprets that in capitalism, work should be such that it maximizes profit for the company and should be exploited as possible for making profit be realized in the maximum possible way (Merino 2010, p. 63). Labor therefore play a major role in the capitalism economy; their purpose, and viability has to be established, as this will help in quantifying the output from every department and comparing it with the cost of hiring the labor and decide whether it is economically sound. To further explain the importance of work in capitalism, reference is made to the industrial revolution when there were many people involved in the production sector. During the industrial revolution, there were several raw materials for industrial productions that were obtained from agrarian revolution that was characterized by increased production from the farms. The western countries particularly wanted to maximize the opportunity by increasing the volume of work force and the hours in which the employees would work in a day (Silk and Mark 1996, p. 53). It will also be remembered that there were rampant child labor that was incorporated into the system to supplement labor requirement. The extent with which work was considered in the industrial revolution, which happened to have been facilitated by the capitalist, explains the rationale behind the consideration of work in capitalist system. There is a strong belief that work and economy goes together and in most cases, economy is considered a function of work and this provides adequate explanation for the situation that was presented during industrial revolution in the western countries. Work Categorized as a Moral in Capitalism With the view of capitalism considering work as a fundamental part of production for the economy to be driven, there are several ways through which work has been considered. The issue of management is geared towards the satisfaction the human resource such that they can be motivated and be enthusiastic to work for more production to be realized (Reich 1991, p. 66). In the management, several incentives are availed to the employees to enhance their efficiencies in performance and the relationship between the employee and the employer is expected to be symbiotic. This can be construed from the principal goal of the management of the human resource; a complete maximum prosperity from the employer and the employee is expected to exist. The use of ‘

Phase 3 Discussion Board Assignment Example | Topics and Well Written Essays - 1000 words - 2

Phase 3 Discussion Board - Assignment Example Based on the above argument, it is my pleasure to report that the most important decision to make is to improve the level of quality of our services. As a production department, there is a need to look for all the available resources which can enable us to improve our efficiency. This means that proper measures should be taken to improve the general conditions of the working environment. If it is properly done, it will have long term benefits to the company since it will be crucial in accomplishing its objectives. The first decision to make is to improve the efficiency of the machines. In the production department, several equipments need to be used. However, for them to be helpful to the company, they should be in a good condition. In this regard, the company should acquire modern and up to date machines to use in the production process. A part from this, deliberate measures should be taken to ensure that the efficiency of the available equipments is improved. This can be done by up dating them and giving them the necessary maintenance. For instance, if there is any worn out part, it should be repaired or replaced. Thus, it will be possible for the organization to improve the efficiency of these machines. The other decision to make is to reorganize the scheduling process of production. In order to be more efficient, it is necessary for the production department to readjust the time schedule of the production process. Since time is a very important resource for the company, it should not be misused any more. Instead, the management should come up with measures to ensure that all the activities are planned (Gomez-Mejia, 2008). Once everything is done as per the schedule, the operations will smoothly run without any delay. This will be a great step towards improving our service delivery. At the same time, it will help in establishing a good rapport with our

Obamas Seven Wasted Years Essay Example | Topics and Well Written Essays - 500 words

Obamas Seven Wasted Years - Essay Example For example, a report released by the National Federation of Independent Business indicated that 85% of the organizations that hired or were trying to hire new workers in the month of November reported that there were only a few or no qualified applicants for the positions they were advertising. Such a report must scare the American society because it is an indication that the educational and professional development system in America has a certain gap. The most concerning aspect of such statistics is that when America is lacking in certain professional qualifications, other major economies in the world such as in Asia and Europe are continuously ranking high in the education quality offered to their people. For example, it is almost certain that students in the same grade in countries such as South Korea, China, and Singapore will outperform their American counterparts in subjects such as mathematics and science. Such information has been in the public limelight for the longest now, but the actual results have just started to show up. The American education system could be deficient in some aspect, and it is a time the gap is discovered and addressed if the future of the nation as the giant global economy will be sustained. According to the Institute of Electrical and Electronics Engineers, only too few students study science or technical subjects in the U.S., such that businesses and organizations cannot find enough workers in these fields. The state of any economy is just as healthy and vibrant as its workforce.

Geared to Success Essay Example | Topics and Well Written Essays - 750 words

Geared to Success - Essay Example One of the things I love to do is playing rugby. It is physically demanding but I love to engage in the sport because of the values such as sportsmanship, teamwork and health benefits I gain from it. Music is another passion that I have engaged in. I can play the guitar drums and keyboard. Looking back to how my parents encouraged me to do a variety of activities in addition to the demands of schoolwork, I now understand that they always wanted me to be exposed to different activities for me to discover my talents and interests. Their efforts paid off because I found out what kind of person I am which affects my planning and decision-making these days. When I went to service trips to Cambodia, Vietnam and Malaysia, I found out how blessed I am to have a supportive family who sends me to school and provides me with my necessities. I have seen a lot of less fortunate children who need to work at a tender age only to help their family eat a meal. I have seen starving babies whose parent s either cannot work or have no work at all because they do not have any skill or means. In the aforementioned countries that I have visited, I have seen a lot of poverty but I also saw how people strive to live decently. Some worked hard to survive the day but they still continue to do their tasks despite their difficult situations. These situations opened my eyes to the realities of life. They have left such an impression to me that I learned to think about my own life, what I am doing about my situation and the things I plan in order for me to have a better life and continue to impact the lives of other people. The realizations did not come to me in a dramatic manner. At first, the impressions did not sink in my mind but after a number of service trips that I attended, slowly, I have come to see more of other people. I became observant of how they lived and then I compared the life that I am living to their lives. Looking back to my familial background, I then came to an understa nding of why my parents reiterated the value of education to me from time to time. I realized that my former attitude of taking things for granted will definitely bring me to a similar state that the people we visited in the different countries were experiencing. It was then that I resolved to do not just what I can in my studies but that, I will exert my best efforts to excel and succeed. As I continued to think about my future, I decided that business is what I would like to engage in as a professional. I know that there are a lot of good jobs and opportunities for me in the business world. However, I am also aware of the difficulties waiting for me. The world is becoming smaller, so they say. With the internet and other technological advancements, the business world is also becoming smaller and expanding at the same time. Businesses are going global nowadays. This means tough competition among businessmen who come from different parts of the world, with different experiences and ideas that could change global economy and their personal paths to success. Therefore, in addition to the lessons I learned, I also have come to understand the value of graduating from a school with good reputations. I believe that when good things are said about a school, it would be because of the quality of services being offered. I know that schools are a great factor in how a person is molded and informed.

Improving the Presidential Election Process Essay

Improving the Presidential Election Process - Essay Example ults collected from primary elections and caucuses are used to determine the number of delegates to be assigned to the national conventions of each party (Sabato, 2006, p 61). The appointed delegates then select the presidential nominees basing on the party’s by-laws for their parties as they move towards November General Elections. This system of undertaking caucuses and presidential primaries is faced with shortcomings when some states hold their primary elections and caucuses earlier than others leading to biased allocation of delegates in each state. On the contrary the process is successful when campaign costs are cut down due to candidates concentrating resources in one state at a time because of the prolonged period of both caucuses and primary elections. According to the United States electoral procedures, delegates elected into the national conventions are charged with the responsibility of nominating official presidential candidates for the two major political parties of the United States (Kendall, 2000, p 56). To provide a balanced electoral system for the primary elections and caucuses, there need to be a balanced primary system where primary contents could be held in between late January and late May. Each state should be assigned a specific time frame and provision for electing 12% of delegates from a single state for party nominations. Using this system will have provisions where larger states will have more positions for additional delegates since the smaller states would have been catered for. In addition, a balanced diversity in the contest could be maximized by pairing liberal states with conservative states and urban areas to be harmonized with rural areas. By implementing this proposed system of conducting both primary elections and caucuses in each state, lesser known political candidates will get an equal chance to be nominated just like their influencing opponents. Furthermore it will cut down on advertising costs and travel time hence

Leadership Recommendation Assignment Example | Topics and Well Written Essays - 1000 words

Leadership Recommendation - Assignment Example The implementation of the new software system for Kudler Fine Foods demands effective leadership approach. With the aim of raising operational efficiency, an introduction of the new automated system will be highly beneficial. The introduction of the new approach aims at replacing the current HRIS system that has been applied by the human resources personnels and store manager. Several data are entailing the personnel files, performance reviews, employee grievances, disciplinary actions and payroll processing. Effective leadership importance and proper leadership styles are very crucial in the process. The importance of the effective leadership during a change management initiative emanates from the essential understanding that only under proper effective process is when the transformation operations will run appropriately. Effective leadership is important since it inspires action. It creates or generates a vision of the forthcoming future that derives inspiration from the people man aging the change process. The system change must have supporters and those who reject it. Effective leadership will outline the advantages of the system to Kudler Fine Foods staffs. Staffs are always associated with negatively and opposing of incoming changes, especially from the administration. Effective leadership will aim at providing optimism and create a general great vision for the adoption of the new model. Effective leadership creates a positivity and removes doubt in the ability of the newly installed system.

Analyzing the Mirror of Sylvia Essay Example for Free

Analyzing the Mirror of Sylvia Essay Sylvia Plath is a name that is famously known in literature as one of the most distinguished female writers of America and the first to receive the prestigious Pulitzer Prize posthumously. Born in Massachusetts on October 27, 1932, she began to have an interest in writing at a very young age. In her whole lifetime, she was able to produce a lot of published works, including an impressive list of poems and stories. In her academic life, Plath has received a lot of prizes and awards including a scholarship to Smith College in 1950 and a Fulbright Scholarship to Cambridge University in 1955. Plath was gifted with an amazing talent in writing, constantly â€Å"was at the top of her class and should logically have been very happy† (Welz). But this was not her case. In fact, Plath was constantly plagued by sufferings and depression. The awards and literary achievements did not always compensate for her feeling of disappointment in herself that is especially emphasized with even just one failure like her suicidal attempt in August of 1953 after she was not accepted to a writing course in Harvard. And yet, people around her were not aware that such depression was forming inside of her because she always projected a happy, contented facade. In a lot of ways, Plath’s personality is always disturbed. She lacked confidence in herself and had a stressful way of viewing life. After he suicide attempt, she was hospitalized â€Å"at Maclean Hospital and was treated with insulin therapy and shock treatments† (Welz). But she continued pursuing her writing which served more than just her passion but as her solace and escape route. In 1956, she met and married her husband who is also a writer, Ted Hughes. Their marriage had been good in the beginning and they produced two children. But in September of 1962, a few months after Plath learned of her husband’s extramarital affairs, the two separated. This is one of the most significant and painful experience in her life. It was evident â€Å"Sylvia had other needs that clashed with her literary ambitions† (Welz). But she did not project this outwardly in her life. As much as she was a very talented and creative writer that was recognized well in the literary society, she also had a lot of personal needs that are often unfulfilled. At some point, Plath also served as an English teacher at Smith College, â€Å"an obvious favorite subject area† (Welz). But she also gave up because she felt dissatisfied and overwhelmed by her work. This led to an increase rate of withdrawal and loneliness, pushing her to write more but limiting her coping and social interaction skills. Most of this feeling was reflected in her poem Mirror that was first written and published in 1961. Mirror was one of the poems that signified a turning point in her style of writing, around the time when life was beginning to become the hardest chapters of her life. The poem is an honest but sad piece of work of that tackles issues of women in the society and in there own selves. It talks about one’s contemplation of all that is hidden and kept, the dream of being accepted, the need to reflect the truth, and the struggle to find one’s importance and purpose in life. â€Å"In Mirror, however, the glass is both subject and speaker at once† (Freedman). It is a poem wherein the object and the author itself are identified as one and they reflect the same qualities and experiences. Plath began the poem by describing the object as something silver and exact. Then, the poem branched out by using a description or characteristic that both the mirror and the author shared through the line â€Å"I have no preconceptions† (Plath line 1). The author’s personality is one that is not prejudiced compared to the others. Just like the mirror, she is truthful to others but remain dishonest to herself. The poem continues with a trait that both the author and the mirror, â€Å"Whatever you see, I swallow immediately† (Plath 2). The author’s personality is to let others dictate how she would feel. There was constant pressure in her part to always do well, having been a model daughter and student her whole life. â€Å"It is the nature and occupation of the mirror self-effacingly to reflect the other† (Freedman). Both the author and the mirror were only passive objects, because they consume whatever is presented to them and reflect it as it is without offering personal beliefs and opinions. It is important to note that the poem was written during the time that Plath had a miscarriage and her marriage with Hughes was facing complications. As a person, Plath was also maturing and becoming more afraid of her life that she feels was completely failing. The second stanza of the poem begins with the line â€Å"Now I am a lake† which reflects a transformation or an evolution that is happening both to the object and to the author (Plath 10). Despite these changes, the purpose they both served remained consistent and the same. The poem reflects that the woman is â€Å"searching my reaches for what she really is† (Plath 11). This indicates the groping for acceptance and importance that everyone is vying for. These are also part of the unfulfilled needs that Plath had her whole life. With everything she had achieved, she still remained discontented because she was not able to embrace her true self and rather rely on other people’s opinions on her. Plath’s experiences, sufferings, frustrations, and dreams in life are definitely reflected in the poem Mirror. As a writer, she was very talented and deserving of her achievements. But as a person, she had a lot of needs that she wasn’t able to voice out and enjoy in her life. It is probably expected that she will take her life again in 1963, and finally succeed. Her unusual, creative, but sometimes overanalyzed perspective in life resulted to a poem as powerful as the Mirror. And the poem’s lines were able to encapsulate the issue of every women seeking for individual identity, fulfillment, and happiness. Works Cited Freedman, William. â€Å"The Monster in Plath’s Mirror. † Papers on Language and Literature. Vol. 108 (5). Oct. , 1993: 152-169. Gale Database: Contemporary Literary Criticism. 1999. Web. 15 July 2010. Retrieved from http://www. sylviaplath. de/plath/freedman. html. Plath, Sylvia. Mirror. Retrieved from http://vmlinux. org/ilse/lit/plath. htm. Welz, Joan. â€Å"Biography of Sylvia Plath. † American Poems. 2009. Web. 15 July 2010. Retrieved from http://www. americanpoems. com/poets/sylviaplath.

The affect of the Mexican Revolution Essay Example for Free

The affect of the Mexican Revolution Essay Francisco Bollain y Goitia Garcia (1882-1960) is a prominent Mexican artists of the XX century, who has been almost forgotten for decades and is now rediscovered. His works are rather complicated for perception and they can hardly be called pleasant, for Goitia concentrated on the most homely aspects of the world around him, demonstrating the fatality of revolution and violent changes in the most shocking way. This paper is to investigate two of his famous paintings – Zacatecas Landscape with Hanged Men I and Zacatecas Landscape with Hanged Men II. The paper is to demonstrate the style and manner of painting, as well as compare those pictures with works of other Mexican painters of the time such as Jose Clemente Orozco and Victor Augustin Cassasola. Some biographical data about Goitia is necessary to understand his works, so the paper shall open with a short biographic reference about the artist. Francisco Goitia was born in the Mexican state of Zacatecas. Being a talented artist since his early years he studied in the Academy of San Carlos in Mexico City and than in Barcelona with the Spanish artist Francisco Gali. Upon return to his home country in 1912 he has found it being wasted by the revolution. Having occupied the position of official painter for General Angel of Pancho Villas army he had an ability to observe war and it’s consequences with his own eyes. The experience influenced Goitia’s works greatly and his paintings are now examples of uncovered brutality and dread. There were even claims that Goitia ordered to exhume executed soldiers and hang them on cactuses as models for his pictures so it is hard to say how much in his paintings comes from real facts and how much from artificial staging of his morbid fantasies. Goitia has never worked with monumental forms so characteristic for Mexican art of the time. His canvases remained inside realism, impressionism and to a great extent symbolism, so he never became so popular as Diego Rivera or Jose Orozco. His last years passed in self-imposed poverty, but still he was quite a famous painter inside Mexico since early 20-s. In recent years his works became of interest for scholars outside Mexico as well. Both landscapes of Zacatecas (I and II) were painted most probably in 1914, although the exact date is unknown. They are both variations about the same topic: a bleak depressive landscape with half-dissolved corpses of hanged men on the trees. Both pictures were drawn from nature. Goitia knew this terrain well since he himself was born in Zacatecas, so he takes almost an intimate and affected position towards the scene. The landscape is typical for northern Mexico – it includes grey and yellow desert land with hills on the horizon and yuccas growing everywhere. The men hanged on the trees seem to their parts – so â€Å"naturally† they are tied to the branches. Most of the researchers point biblical analogies in the first painting for the landscape is so bleak that it reminds Golgotha. The analogy becomes even stronger for Goitia called his series of paintings about revolution â€Å"martyrdoms†. Goitia has been in the army of Pancho Villa in 1914 when he has captured the capital city of Zacatecas. Being both fascinated and frightened by that what he has seen he started feeling that his mission was to record the epic events of the revolution for history. As he himself put it â€Å"I went everywhere with the army, observing. I did not carry any weapons because I knew that the mission of killing was not mine† . Among the things Goitia has witnessed was death of general Lazaro Gomez, who has been repulsing enemy attacks auntill he ran out of ammunition and shot to his back after being taken prisoner. The body of the general has been beheaded and hanged on a tree with his head replaced with the head of a steer. It is believed that exactly death of Gomez inspired Goitia to paint his Zacatecas Landscape with Hanged Men I, although he used bodies of simple soldiers as â€Å"models†. So the first variant of the painting can really be considered a record of actual events, although Goitia did not concentrate on the death of a particular man, but aimed to show the series of deaths in Zacatecas. The most obvious difference between two variants of paintings is the manner in which they are drawn and involvement of the spectator. Zacatecas I still looks like a â€Å"real† classical painting with obvious elements attributable to artistic form including shape, symmetry, movement and rhythm. The background plays an active role in the picture and the bodies of the hanged look simply like the bodies of the hanged. They are horrible and shocking, but at least â€Å"natural†. Perhaps Goitia was not satisfied with the artistic effect of the first painting, so in the second variant he made it more impressive and less realistic . This was necessary to strike the audience in the necessary way. In the second painting two dead bodies are absolute centre of the compositions, and their empty eyeholes are pointed directly ad the spectator, as if they were looking at him. The position of the bodies creates an impression of surrealistic â€Å"gates† to the dreadful reality of death and grief. Death and it’s triumph are key points of the picture. The first variant is painted with oil on canvas and the second one looks more like a touchy pencil drawing, which has later been colored. To make his second painting even more symbolic Goitia replaced usual terrain of Zacatecas with surrealistic vision of deadly symbolism. In Zacatecas Landscape with Hanged Men II the trees seem to come out from gothic descriptions of Poe as they are gnarled and lifeless being painted with pale cold colors. Skulls of animals on the ground once more stress that death is a true master of the stage. The only living creatures on the second painting are owls – traditional symbols of night and forerunners of death. They create a ghostly atmosphere of the scene. Bodies are waved to different sides paralleling the braches they hang on, so they seem to be blown by different winds. White sun in the grey skies creates an image of omen. The general impression from the first picture is that Goitia painted that what he has seen and the second picture is undoubtedly a manifesto of his views, in which he tried to impress the observers by shocking view of horrifying images. As it has been already mentioned, the paintings belong to Goitia’s revolutionary period when he worked as a painter of Mexican federal army. The revolution in Mexico lasted from 1910 till 1917. Some scholars believe that Cristero rebellion of 1926-1929 was also a part of the revolution, so revolutionary events lasted in Mexico for almost two decades. Goitia’s paintings are images of that what virtually every Mexican of the time has once experienced, and this is perhaps the main reason why Goitia is so popular in Mexico and less famous outside its borders. It is hard to say for sure whether Goitia was an active supporter of the revolution or just followed the army as a chronicler. His later memoirs seem to support the second point of view – Goitia remained an artist but not a revolutionary throughout his travels after the army. The manner of paintings and their impression also correspond to the version. He has never painted any picture in which he would admire revolution, but both paintings seem rather to blame its barbarity. The manner of Goitia’s painting reminds the most famous apocalyptic pictures such as Triumph of Death by Peter Breugel, descriptions of war by Goya or Picasso’s Guernica. Most of the revolutionary painters glorify its triumphs and view it as a way to the new world. Goitia has chosen to demonstrate the horrifying â€Å"side effects† of progressive social upheavals. This was enough for him to be considered one of the sharpest critics of revolution in art. He explained that: â€Å"You see that it is natural that circumstances have made my temperament more inclined to the profound. There is a great deal of sadness in this country and I have tried to sum a certain phase of it† . Such Goitia’s insights are rather unusual for Mexico of the time, where revolution became almost a national idea, reflected in numerous artworks. This includes frescos by Diego Rivera or monumental modernist paintings of Jose Clemente Orozco. Mexican artists of the time shared different views of the revolution but there was one common thing for all of them – for them revolution was a magnificent event, a high tide of spirit and will, but in no way a vision of death and destruction. For example Diego Rivera was an incandescent Trotskyist, absolutizing the idea of global revolution and idealizing Trotsky as its dramatic leader. Orozco is a more complicated case for he was interested more in changes that revolution would cause in human minds and in the society. Still his art stands closer to the supporters of revolution as he used expressive modernist techniques being a revolutionary artist by his mere nature. And another common point of Rivera and Orozco is that they both are working with â€Å"objective reality† using artistic means to make the spectator impressed by this reality . In contrast, Goitia’s paintings are full of his own attitudes and they allow the spectator to make his. Revolutionary artists provided only one view, Goitia allowed the audience to chose. Although it is hard to find a â€Å"colleague† for Goitia between painters, such â€Å"colleague† still existed among photographers. Augustin Casasola in fact worked for the newspapers, but he would remain a usual reporter in case his pictures were not full of artistic sense, making them close to Goitia’s graphic works. As the revolution spread along Mexico Casasola established his own agency to provide home and foreign press with photographs of the event. Working as an independent photographer he was able to use his talent in full. he concentrated on all aspects of the revolution showing both victories and, like Goitia, the unattractive sides. He has also gathered a large collection of images of revolutionary individuals – from officers to peasants in their surroundings. Like Goitia his manner has been characterized by psychological dramatics and involvement of the spectator to the picture . Warlike and revolutionary art is always popular because there are always lots of people who are ready to admire the triumph of spirit and epic deeds. Less popular is art that shows the another side of war and revolution – death and destruction. To show this side the painter needs to be much more talented and avoid being just a thrilling entertainment. For this reason only a few painters became great after painting atrocities of war. Goitia is perhaps not so famous as Goya, but his works are deeply original.For this reason he is now being rediscovered and investigated by art historians worldwide. Works Cited: 1. Dore Ashton. (1999) Mexican Art of the Twentieth Century. In The 20th Century Art Book. ed. by Editors of Phaidon Press 2. Jacqueline Barnitz (2001) Twentieth-Century Art of Latin America University of Texas Press 3. Latin American Painting available at: http://www. chicagomanualofstyle. org/tools_citationguide. html (last accessed: November 19, 2007) 4. Viva Casasola! http://emiliobrizzi. blogspot. com/2007/03/viva-casasola. html (last accessed: November 19, 2007)

Comparison of unusual administration methods of morphine

Comparison of unusual administration methods of morphine Morphine is a widely used analgesic. Its clinical use and the high dependency factor (morphine and heroin have proven to be the most addictive opiates) brought up the need to investigate the classic routes of administration (oral, rectal, iv, sc) and compare them with some not so well established routes (nebulised, intrathecal, transdermal, sublingual etc). Introduction Morphine is a strong opioid derived from the opium poppy, Papaver somniferum1. It is used for the management of moderate and severe pain. It acts directly to central nervous system exhibiting a quick time of action. Along with pain relief, it causes the sense of well being (euphoria). It can also produce a series of other central and peripheral effects such as sedation, cough suppression, nausea, constipation and might cause histamine release2. It is used during surgeries for anaesthesia and as a pain reliever after the operation. It is a drug of choice for terminal care and it is really useful for pain management in cancer patients3. Morphine is available at several formulations and different drug administration routes. The selection of the appropriate administration route is dependent on the extent of pain control required. For instance, parenteral morphine is used for acute severe pain, while oral morphine is used for the treatment of temporary pain. The location of the pain will also determine if it is necessary to apply topical preparations or not. Table 1 Pharmacokinetic Properties of three opioid analgesics Pharmacokinetic Parameters Half life Volume of Distribution Clearance Morphine (iv) 2-3 hours   3-5 litre/kg 15 -20ml/min/kg Fentanyl (iv) 3.5-3.8 hours 5-6 litre/kg 21-29ml/min/kg Diamorphine(iv) 2-3 minutes 25litre/kg Use morphine values Source: Clarkes analysis of drugs and poisons4 Moreover, pharmacokinetic parameters such as bioavailability, half life and clearance and other characteristics of the drug (table 1) like side effects, ADRs and interactions must be taken into account before choosing the appropriate drug route. Patients preference (or fear) for a specific drug route and other psychosocial factors might also affect the choice of the formulation and patients compliance and finally medicines effectiveness. Discussion Oral route Regarding oral route, morphine comes as a solution and as immediate or controlled (systained) release tablets and capsules(fig 2). Fig 2. Oral formulations of morphine Oral Suspension Morphine solutions come in different strengths. Oral solutions can be prescribed by writing the formula Morphine HCl 5mg and Chloroform water to 5ml but the proportion can be altered. Morphine Sulphate solutions (Oramorph) are available at 10mg/5ml and as concentrated solutions of 100mg/5ml3. Other excipients include: ethanol (96%- morphine is slightly soluble in ethanol), corn syrup, sucrose, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216) and purified water. Due to the high content of alcohol this drug is not recommended to alcohol misusers. Normal adult dose is 10-20mg every four hours although when prescribed in palliative care dosage varies higher or lower according to the severity of the pain and kidney function respectively3. As this formulation is not readily absorbed from GI tract, in order to produce same effects as iv dose a 50%-100% increase in dose must be considered. Overdose risk is high and can cause hypotension, respiratory depression and in some cases death. Naloxone which is an opiate antagonist is the first line treatment in case of overdosing5. Tablets and Capsules Solid dosage forms contain morphine in form of salt e.g Morphine Sulphate and Morphine hydrochlorate. Theses salts in the body will be available as morphine bases. Tablets are available in two preparations immediate release and modified release. The short acting tablets come in 10mg, 20mg and 50mg3. They are given every 2-4 hours to control and stabilise breakthrough pain. These tablets are a way of determining the amount of morphine needed to manage pain. Once the quantity of morphine is established the patient can take slow-release tablets and capsules. These formulations contain enough morphine to control pain for 12 or 24 hours. The starting dose varies and from 10-20mg every 12hours if the patient has not taken any other painkiller previously, to 20-30 mg every 12 hours in cases of replacement weak analgesics3. Note only the dose can increase whereas the frequency must remain the same i.e. every 12 hours. It can take up to 48 hours for the morphine to reach the required plasma levels meaning that it is important to be taken regularly otherwise they lose their effectiveness5. If the patience experience pain between doses an additional dose must be given and the GP should decide if it is necessary to increase the daily dose. Oral morphine is a well established drug delivery method however; problems such as the first pass metabolism, the slow onset and the risk of overdose have raised questions on whether other novel administration routes can be used. Intravenous This route is used only in hospitals and in managing emergency pain symptoms. The bolus administration provides almost instant onset with a short effect. Iv morphine is used when sc route is not tolerated. A popular application of this method is in Patient Controlled analgesia (PCA) where the opioid is delivered using a Hospiral infusion device. The patient can control the morphine intake and establish an acceptable level of analgesia6. Morphine is available in 50 and 100ml vials with strength 1mg/ml3. It is used post operatively especially after transplants surgeries and in the management of chronic pain of malignancy. Although this method is useful for the management of severe pain there are many drawbacks. First of all, most of the pumps are bulky and invasive. Their installation is complicated as they require mains attachment and the patient has limited mobility .There is a high risk of overdose therefore supervision is needed. Side effects such as hypotension and respiratory dep ression might develop while convulsions due to high dosage are likely to occur. fig3. PCA infusion device vs syringe driver Subcutaneous Subcutaneous method is an excellent alternative to oral administration method. It is safe and effective method which is widely used both in palliative care and severe pain management. It is used for patients that present conditions such as gastrointestinal disturbances including indigestion, palindromic motility and obstruction5. A prime characteristic of the sc method is the syringe driver. The driver employs simple syringes and bears a flow rate setting option usually ml/hr which enables accurate dosing over a specific period of time. Unlike PCA infusion devices, it is battery powered, so patients mobility is not an issue (fig 3). The risk of overdose is lower compared to iv route as there is a constant stable administration schedule6. There is no need for continuous strict supervision as the driver is easy to use. Often, the subcutaneous route can cause some skin site problems. Irritation might appear especially when there are high concentrations of morphine or when it is combined with other drugs which are not fully compatible3. This problem can be treated either by diluting the dose or by choosing alternative more compatible drugs. Also some patients might experience needle allergic reactions and action must be taken e.g introduce an alternative Teflon cannula. Patients might feel discomfort, especially those who lack of subcutaneous tissue16. Sometimes, possible leakage of subcutaneous site might be observed. Finally, the sc method is not recommended for palliative care patients with acute vascular conditions. Rectal This drug administration route is quite popular and is used for short term management of acute pain. Also in terminal cancer patients modified release morphine sulphate is administered via this route6. Although the absorption rate varies for each individual, it is estimated that around 300-330 mg of morphine are absorbed rectally every four hours, indicating a sufficient analgesic effect. Studies have shown that for the patients who have never taken morphine, rectal morphine is more effective than the oral administered one5. Rectal morphine is available in the form of suppositories at different strengths (10, 15, 20 and 30 mg) 3. Prescribers must specify both the strength and the morphine salt (morphine hydrochloride or morphine sulphate) that suppositories should contain. Evidence shows two deaths15 after consequent doses of rectal morphine should raise awareness and the need of monitoring the dosing regimen and frequency. Rectal route is not avoiding completely the first pass metabolism; therefore the bioavailability might be influenced. Non conventional routes Apart from the conventional drug routes mentioned before, it is necessary to look into other not so popular ones such as the transmucosal, transdermal, sublingual, intrathecal and nebulised routes of administration and try to compare them. Transdermal- Transmucosal Transdermal route is a relatively painless method. The drug absorption is rapidly. Patches are easy to use and not quite expensive. Although this method is usually tolerated from the patients skin irritation and rashes might appear. Transdermal morphine is not popular as there are questions about the efficacy of this method. However, fentanyl another opioid is the drug of choice. More specifically, fentanyl patches are more effective in managing chronic pain compared to modified release oral morphine9. Also, transdermal fentanyl causes reduced constipation and drowsiness14. Another administration route which fentanyl is again preferred than morphine is the transmucosal route by a buccal tablet. The main reason is that fentanyl is a lipophilic drug while morphine has a limited lipid solubility. More specifically, when fentanyl is placed in saliva it is 80% non-ionized  and it usually takes 20-30 minutes for the analgesic effect to reach its peak14. Note transmucosal morphine is also available but the bioavailability is low and analgesic effect is not significant. Sublingual route This route utilises soluble immediate release tablets and it is recommended to patients that have swallowing difficulties. Morphine enters into bloodstream via sublingual mucosa. Investigations have shown that the absorption of morphine is the same (and in a few cases faster) compared with the oral route7. Same studies have shown that there is no significant difference in the extent and duration of analgesic effect when is compared with oral administered morphine3. Nebulised morphine Nebulised morphine utilises the airways to deliver the drug into pulmonary circulation. It can be used for COPD patients in the management of acute thoracic pain11. Through this route, the effect of hepatic metabolism is avoided and a rapid absorption is noted. However, the plasma drug levels are unpredictable indicating the necessity of further clinical investigations. Studies showed that inhaled morphine was as effective as intravenous PCA morphine without causing strong sedating symptoms8. Although nebulised morphine is well accepted, patients who are not used to opioids might experience nausea and vomiting and in rare cases respiratory depression. Other common side effects include constipation and histamine induced broncho-constriction. Another drawback of nebulised morphine is the high cost of the equipment (nebuliser, injectable vials, etc). It is not a simple method and some patients might find it difficult to use the nebuliser. Studies show a wide range of bioavailability in subjects; relating the bioavailability of the drug with the patients ability to use the nebuliser in the right way10. Epidural/intrathecal Both epidural and intrathecal routes are used mostly in the hospital clinical environment. The bioavailability is high so spinal administered morphine can provide extended analgesic effect at lower doses (compared to the conventional drug routes)12. Although epidural and intrathecal morphine can relieve both acute and chronic pain; studies suggest that these routes should be used only for pain which cannot be controlled by the classic established methods13. For instance, these routes are effective in managing lower body pain. Note that only 1% of the daily iv dose must be used intrathecally and only 10% epidurally5. An implanted infusion pump may be used to deliver intrathecal morphine at a continuous rate. A disadvantage of these methods is the high risk of infection and overdose as the staff must be trained and careful when dosing for breakthrough pains. Studies have reported a number of patients experiencing side effects such as sedation, dyspnoea, nausea and vomiting after spinal administration12. Spinal morphine is not usually preferred while diamorphine is the drug of choice due to its high solubility manner. Conclusion As it was mentioned before, morphine can be administered via different routes. However, it is vital each time to consider the risk- benefit ratio for each method and choose the most effective and safe one. Moreover, before establishing unconventional methods such as nebulised and spinal morphine it is important to further investigate their suitability and ways to improve the drug delivery and minimise side effects. Finally, if it is necessary to choose other opiates (such as fentanyl and diamorphine), which might be more efficient than morphine.

Book VII of the Nichomachean Ethics by Aristotle Essay -- Aristotle Ni

Book VII of the Nichomachean Ethics by Aristotle Introduction In book seven of the Nicomachean Ethics, Aristotle sets out his theory of akrasia, or weakness of will. Aristotle attempts to explain both how such actions are possible (contra Socrates), and how we can dissolve the puzzles (aporiai) generated by our most important (kurios) commonly held beliefs, which arise in response to the actions of the incontinent person. This paper will review book VII of the Nichomachean Ethics (EN), and attempt to resolve some of the remaining questions left open by Aristotle’s critique. According to Aristotle, ethika is not an exact (akribes) science, for it only provides â€Å"usual† truths (hos epi to polu), or those that are true for most, but not all, cases. Ethics is a practical discipline, which depends on the prudent person to make competent decisions with respect to various particular cases; unsurprisingly, it would be difficult (if not impossible) to determine any invariant rules of application for every ethical situation. Accordingly, Aristotle consults the opinions of the common majority as an initial starting point from which to proceed in ethical study. The beliefs of the hoi polloi are revisable, however, and in the case of incontinence, we shall see that Aristotle cannot resolve all of the puzzles resulting from them. The format of this paper will proceed as follows. First, we will attempt a rough description of Aristotle’s conception of incontinence. Next, we will survey the most salient puzzles with which he is concerned. Subsequently, we will attempt to resolve any remaining questions concerning the plausibility of Aristotle’s theory. Section One Aristotle’s conception of inc... ...ned earlier, we remain convinced that the incontinent knows the entire time that what she does is the wrong thing to do. If we think she doesn’t know, or forgets momentarily, then why is she morally responsible for her wrong-doing? Likewise, Aristotle’s own explanation lacks enough specificity as to why and how the appetite makes one â€Å"unaware† of the good conclusion. Simply put, the ambiguity interpretation is the most plausible way to account for both our pre-theoretical intuitions and our everyday practical experiences. In this respect, it remains true to the spirit of the Nichomachean Ethics. Works Cited Aristotle. Nicomachean Ethics, Translated by Terence Irwin. Second Edition. Indianapolis: Hackett Publishing Company, Inc. 1999. Davidson, Donald. â€Å"How is weakness of the will possible?† in Essays on Actions and Events. Oxford: Clarendon Press. 1980.

Importance of Clothing in Prologue of the Canterbury Tales :: Canterbury Tales Essays

Importance of Clothing in Prologue of the Canterbury Tales Countless people believe in the cliche "do not judge a book by its cover": but why not? Clothing often forms another's first impression of one. It speaks of where a person has been and where they intend to go. Their appearance also illustrates a person's true self and aspirations. A man wearing torn jeans, dingy shirt, and old shoes might be thought of as poor or coming home from a hard day's labor. However, a young woman in a Gucci dress with Versace pumps could be assumed to have access to a large amount of money. In "The Prologue from the Canterbury Tales," Chaucer uses clothing as an insight into people's ongoing adventure called life. In the Prologue, humbled by his life experiences, the Knight dresses plainly. Garbed in a stained coarse cotton tunic, the knight sits upon his horse. Seen in a different setting, the Knight's attire would say little about his life as an honorable man. By humbling oneself, a true hero lends credence to the fact that flash is not always needed. His armor left dark smudges on his tunic. Humbling experiences cause humans to step back and analyze the fortune they have; they learn that they do not have to wear their achievements. Sometimes people boast their success through fine clothing. Unlike the flamboyant Yeomen, the distinguished knight wears old garments. The Yeomen succumbs to society's inclination that when he dresses the part he will become successful. He wears a coat with a green hood. From a low social standing, he believes that the better he looks the more successful he will become. Emphasis should be placed on one's achievements and inner self rather than outward appearance. A saucy brace is worn on his arm to protect it from the bow. At first glance, one would assume that he was a superior archer of high standings rather then a lowly Yeomen. Looks can be deceiving, but the illusion fades as one's true self shines through. Extravagant best describes the Yeomen's style while plain and reserved best depicts the nun. Chaucer illustrates how small insignificant accessories can have a deeper meaning. The Nun wore a coral trinket on her arm.

Louis XVI

Louis XVI was born on August 23rd, 1754 in the Palace of Versailles. He was born Louis Auguste, duc de Berry to Louis, the Dauphin of France, and Marie-Joseph of Saxony. Louis was neglected as a child in favor of his older brother, Louis, duc de Bourgogne, until he died at age seven. He was a shy and overweight. After the death of his father in 1765, Louis became the new Dauphin of France. He received strict education from the Duc de La Vauguyon, which did not sufficiently prepare him to be king. On May 16th,1770, at the age of fifteen, Louis married 14 year old Archduchess Marie Antoinette, the youngest daughter of Holy Roman Emperor Francis I and Empress Maria Theresa. This marriage signified an alliance between France and Austria. The royal couple failed to produce an heir, later discovered to be due to Louis's sexual dysfunction. In 1774, Louis inherited the throne at 20 years old and became King Louis XVI. Despite his title, he had no qualities of a ruler and was extremely unqualified for the job. Nonetheless, he was faced with a government in deep debt and a clamor for resentment against monarchy. Louis XVI began by reinstating the parlements to gain the trust of his people. He was determined to be a good monarch. France however was an in an economic crisis. To deal with this, Louis appointed Jacques Necker as his financial advisor. Louis convoked the Estates General, but eventually removed them, causing great anger in the public. This caused the creation of the Third Estate, the National Assembly, and the Tennis Court Oath on June 20th that sparked the French Revolution. The Storming of the Bastille on July 14th confirmed the radical change in the mind of the masses towards the monarchy. French involvement in the Seven Years War left France in a disastrous economic state. Louis XVI sought to seek revenge on Britain by aiding the Americans in the American Revolution. He was eventually convinced by American Ambassador Benjamin Franklin to secretly send supplies, ammunition, and weapons to the Americans. He personally sent Rochambeau and Admiral de Grasse to aid the cause, along with a large land and naval force. Louis XVI also wished to expel the British from India. In 1782, he sealed an alliance with the Peshwa Mandhu Rao Narayan. This begun the French struggle to eliminate British control in India. On October 5th, 1789, an angry mob of Parisian working women marched on the Palace of Versailles and attempted to kill the queen. Her wasteful and extravagant lifestyle represented all that was despised about the Ancien Regime. The King and his family was then moved from Versailles to the Tuileries Palace in Paris. In June of 1791, Louis attempted to secretly flee with his family from Paris to the royalist fortress town of Montemedy on the northeastern border of France. However, they were discovered in a small town in the country and immediately taken back to Paris and placed under house arrest in the Tuileries Palace. In August of 1792, Louis was officially arrested and sent to the Temple prison. On January 15th, 1793, the Convention, composed of 721 deputies, voted King Louis XVI guilty for colluding with the Austrian invaders whom France was at war with. On Monday, January 21st, 1793, Louis XVI was stripped of all titles and honorifics by the Republic Government. On the Place de la Revolution, Citoyen Louis Capet was executed by the â€Å"national razor,† the guillotine. On May 16th,1770, at the age of fifteen, Louis married 14 year old Archduchess Marie Antoinette, the youngest daughter of Holy Roman Emperor Francis I and Empress Maria Theresa. This marriage signified an alliance between France and Austria. The royal couple failed to produce an heir, later discovered to be due to Louis's sexual dysfunction. In 1774, Louis inherited the throne at 20 years old and became King Louis XVI. Despite his title, he had no qualities of a ruler and was extremely unqualified for the job. Nonetheless, he was faced with a government in deep debt and a clamor for resentment against monarchy. Louis XVI began by reinstating the parlements to gain the trust of his people. He was determined to be a good monarch. France however was an in an economic crisis. To deal with this, Louis appointed Jacques Necker as his financial advisor. Louis convoked the Estates General, but eventually removed them, causing great anger in the public. This caused the creation of the Third Estate, the National Assembly, and the Tennis Court Oath on June 20th that sparked the French Revolution. The Storming of the Bastille on July 14th confirmed the radical change in the mind of the masses towards the monarchy. French involvement in the Seven Years War left France in a disastrous economic state. Louis XVI sought to seek revenge on Britain by aiding the Americans in the American Revolution. He was eventually convinced by American Ambassador Benjamin Franklin to secretly send supplies, ammunition, and weapons to the Americans. He personally sent Rochambeau and Admiral de Grasse to aid the cause, along with a large land and naval force. Louis XVI also wished to expel the British from India. In 1782, he sealed an alliance with the Peshwa Mandhu Rao Narayan. This begun the French struggle to eliminate British control in India. On October 5th, 1789, an angry mob of Parisian working women marched on the Palace of Versailles and attempted to kill the queen. Her wasteful and extravagant lifestyle represented all that was despised about the Ancien Regime. The King and his family was then moved from Versailles to the Tuileries Palace in Paris. In June of 1791, Louis attempted to secretly flee with his family from Paris to the royalist fortress town of Montemedy on the northeastern border of France. However, they were discovered in a small town in the country and immediately taken back to Paris and placed under house arrest in the Tuileries Palace. In August of 1792, Louis was officially arrested and sent to the Temple prison. On January 15th, 1793, the Convention, composed of 721 deputies, voted King Louis XVI guilty for colluding with the Austrian invaders whom France was at war with. On Monday, January 21st, 1793, Louis XVI was stripped of all titles and honorifics by the Republic Government. On the Place de la Revolution, Citoyen Louis Capet was executed by the â€Å"national razor,† the guillotine.

Macro Utiliized Within Microsoft

Microsoft Word is a program used in school or business to create, edit, print, and you can also publish documents to the internet or web. What you need is Microsoft Word however it comes in the MS Office package along with other software like Powering, Excel, etc. It is not going to cause you any additional problems. You will most likely need these other programs in college as well. You are mostly interested in Microsoft Word so let me explain some of the features of Microsoft Word.You will be able to: 1. Cutting, Coping and Pasting 2. Formatting text which Is used to adding colors, graphics also font size and type 3. Adding images or object and pictures from your computer or the web 4. Find, search and replace a single word or paragraphs within the document with ease 5. Bullets and Borders from with Word or online is available and can be used to decorate the document and any important points you want to make 6. Spelling and Grammar comes at great ease with this software 7.Document P rotection Is available and you an require a password and also have signature required 8. Also can be used to create letters and mailing envelopes This is among tons of other features that are available to you. If this conversation takes place over the phone I would use my customer service experience (friendly, courteous) to greet customer and start the conversation. I would give my name and politely ask for the customer name so I can address them by name for the rest of the call. It makes them feels comfortable.I would then thank them person for calling tech purport and asking how can I help them? One challenge would be that the customer has no Idea what I am talking about or no knowledge of Microsoft Word at all. In this Instance I would let the customer know they can call back for a tech or me to walk them through a training session. I can also email a video link to the customer to watch so they can get familiar with the software. I would clarify what the problem Is or any questio ns described by the customer, and answer accordingly.I do not assume there will be many problem on this call. This call Is an Informational call only and actually the sales rep would have gotten this call not tech support. There Is again no step-by-step process for this customer so this question does not apply. My alternative or follow up to all calls would be to send an email regarding Information discussed In the phone call. However, the customer can always vaults the website and browse through all of the same Information and read It at their own pace.Also, download the trial for the software and give It a try for free and get comfortable with he software before purchasing It of course. Macro Utilized Within Microsoft By Stationmaster 2. Formatting text which is used to adding colors, graphics also font size and type 3. Comes at great ease with this software 7. Document Protection is available and you has no idea what I am talking about or no knowledge of Microsoft Word at all. In this instance I would let the customer know they can call back for a tech or me to walk watch so they can get familiar with the software.I would clarify what the problem is assume there will be many problem on this call. This call is an informational call only and actually the sales rep would have gotten this call not tech support. There is again alternative or follow up to all calls would be to send an email regarding information discussed in the phone call. However, the customer can always visit the website and browse through all of the same information and read it at their own pace. Also, download the trial for the software and give it a try for free and get comfortable with the software before purchasing it of course.

Business plan for men skin care

I hope that the loan application will be approved as soon as possible -We really appreciate and we are grateful towards your consideration of approving our loan, as we look forward to hear from you soon. Thank you Yours Truly, 2. Executive Summary The Retro Skincare is a new business providing high-quality, full service distribution of skincare products specialty in moisturizing skin products and whitening product. Our product supplier is Reuben Skinner Company. Reuben Skinner Company is the sole manufacturer of the skincare product and located in Saba.In particular, what really sets up apart is that we are the ONLY full service distribution company servicing the skincare products around Slang Valley. In addition, Reuben Skinner Company has an exclusive contract to distribute a new, groundbreaking product that loud enable us to gain immediate access to a majority of the potential customer base. The principal owner is Subheadings, experience brings office management, high levels of cu stomer service, and over 20 years in distribution and sales management.At this time we are seeking additional equity capital to compliment our own investment and are seeking to arrange a bank line for inventory and receivables financing. Having firm commitments to distribute several high-quality new age skincare products we plan to distribute our first products within 30-60 days of finalizing financial arrangements. Our target customers are men located in urban areas and retailers. Our targeted end user is between the ages of 24 and 65. They are urban professionals with at least some college.Pricing of our products are ranging from ARM 17- ARMS per unit. 3. Introduction Reuben Skinner Company to customers in Malaysia. This will accomplished through a combination of company- owned retail outlet and wholesale distribution. The Retro Skincare will purchase product directly from manufacturer to eliminate the middle man and allows us to operate on a 25-30% profit margin, while providing our customers with competitive prices. The proposed location for Retro Skincare is Clan Marrow, Bangs. The principal owner is Subheadings.Distinguishing characteristics of our business will be the combination of management experience, sales and distribution experience, high- quality, innovative products and exceptional customer service. 4. Business Objectives and Mission 4. 1 . Objective To open and operate a successful skincare product distributorship in the Slang Valley market, employing three to five employees the first year. To obtain a minimum of 100 regular customers in the skincare market the first year of operation. Achieve first year ales of ARM 40,000. Maintain an average gross margin of 25 percent.To produce a net profit of at least OROMO,OHO by the end of the third year of operation. 4. 2. Mission The Retro Skincare intends to become a recognized distributor of specialty skincare products and spreading it around Slang Valley. The Retro Skincare plans to develop strong re lationships with key customers so we will be viewed as indispensable partners, rather than Just another supplier. The Retro Skincare will seek out and work with the manufacturers we represent to deliver the most innovative and exciting products possible to the customers we serve.We are not only selling product, we are selling service. † 5. 1. Industry Description and Analysis Skincare is one of the largest industry in the world. Technological advancement in the skin care market combined with development of innovative products contributing to the growth of skin care industry. The increasing demand for anti-ageing products and growing concern for the use of natural and organic skin care products are the major factors driving the skin care industry. In estimation, Malaysian annually spend an estimated ARM 3. Million on skincare products and cosmetics. By reason of lath awareness and aggressive product branding, consumers spend large amount of their income in buying skin care prod ucts. Malaysian skincare concerns include the heat and humidity of the climate, the drying effect of skin, stress and lightening the skin and areas of hyper pigmentation, acne, and the effect of aging on the skin. These concerns translate into strong prospects for skincare products and remain in broad consumption across all age and income groups in Malaysia.International brands such as Lance, L'Oreal Paris, Lola, Esteem Lauder, Clique and Sheikdom play a dominant role in the upper-end market of Malaysia. Imported products are highly in demand as most of the middle and high-income earners associate imported products with higher quality than local brands. The cosmetic giants still hold a dominant position in this industry and they will most likely continue to. But they have realized the need to acquire new brands and to keep their affiliation in the background. In recent year, names like Grainier, Dashing men, Naive have been acquired as local skin care products.This strategy indicate s that a few of the traditional big players recognize the benefits, for themselves and the industry, of emerging niche brands. 5. 2. Industry Trend Rapid arbitration in Malaysia resulted in strong demand for skin care products from both men and women. Sales for 2013, the most recent year available, were up to 45 percent, almost double the industry average of 20 percent. Soap is losing popularity as a facial skincare product, with the proportion of female users falling from 58% in 2008 to around (36%) in 2013.Due to skin dryness, women are attracted with emergence of facial and skin care products such as cleanser and moisturizing cream which make their skin healthy. At earlier, there are no skin care products use facial skincare products than women. Men's reactive approach to their skincare regime is the biggest challenge facing the industry Nowadays, men consumers can find some brand new skincare products of men almost in all grocery shops and supermarkets. An increasing number of c onsumers exposed to wide variety of skin care products like skin care products enhanced with collagen and other natural ingredients.Due to increasing disposable incomes and stronger consumer purchasing confidence in 2012, strong demand was seen for skin care products, particularly mass brands, since consumers could afford them to enhance or maintain their skin condition. Malaysian favor nature-inspired products mainly. If current trend play out as expected, the business of skin care products for men will become increasingly consolidated among other industry. The unique properties of men's skin need to be addressed in these new products (smaller sebaceous glands, oily skin, thicker skin etc. So that the products work effectively and the user experiences noticeable results more rapidly. 6. Market Segmentation Research 6. 1 . Market Analysis Summary The demand for man's skin care products are certainly on the rise as men are paying more attention to their appearance. According to resea rch conducted by Retro Skincare, six in 10 (65%) Malaysian men consider their appearance important and almost (48%) admit what they want to look attractive and well groomed. Just 15% of men admit that while it is acceptable for women to use skincare products, it is not acceptable for men to use such products.Highlighting the growing importance of the men's facial skincare market, today, as many as 7% of men admit to spending a lot of time on their facial skincare routine. Research highlights more than four in ten (42%) men use shaving lotions and almost a quarter (22%) use facial cleanser. 12% of men SE eye cream and gels , 17% use anti ageing products and 7% use moisturizer. While many of the nation's men are adopting a regular skincare regime, it remains that a lower proportion of men use facial skincare products than women.Men's reactive approach to their skincare regime is the biggest challenge facing the industry. Encouraging men to adopt a more preventative approach to their s kin's demographic changes in both mature and emerging markets: an increased number of men employed in the sector of services, increased competition in the workplace, ageing baby boomers eager to stay stylish, and the young generation influenced by hanging standards of male beauty. New entrants on the markets, as well as technologically advanced products, expanded lines, and innovative packaging are also stimulating sales. . 2. Market Segmentation To keep up with demand, the men's skin care market is becoming more segmented and expanding into new categories and claims. Generally, skin care market for male can be segmented based on four main segments: geographic, demographic, cryptographic and behavior. For the purpose of this analysis we are focusing solely on the male market. New research from Minute reveals that beauty and personal care munches specifically targeted at men have increased globally by 70% over the past six years (2007-2012).Its stated the market for facial skincare h as increased an impressive 20% in the last five years alone, valued at El,l billion in 2012, the market is set to reach a beautiful El,2 billion in 2017. L. Demographic: Retro Skincare target market is the retailers who have established relationships with consumers and the consumers themselves. We are essentially the distributing arm for these retailers. Our market research indicates about 46 potential retailers within a 1 to 25 mile radius of our location, who currently sell our competitors reduces. Our target retailers are drugstores and pharmacies.Another target market is men (end user). There are 30,001 ,710 individuals in Malaysia and 5,315,008 are male adults 18 to 65, which are our target consumer market. They are urban professionals with at least some college. This consumer has an active lifestyle. They are concerned about social and environmental issues. Mind and body wellness are important to them. Sales have been sustained as increasing numbers of young men are interested in capturing the stylish looks of media stars while older men have paid more attention to keep their skin younger as their younger days.Therefore, older men will give more attention to anti-aging products while young men will look for skin whitening products and moisturizer. Some youngsters will opt for acne free skin products. Our products can be used by any group of incoming level. Malaysia's men working under heat weather will buy sun block and skin care product which lighten the skin and areas of hyper pigmentation. Demographic factors such as the rising number of single-occupancy households, as consumers delay committing to marriage and children, have led to a growing number of men doing their own shopping, with ore disposable income to spend on themselves.Retro Skincare found out that single customers purchase a certain product more frequently than married people. II. Geographic: Men in different climatic conditions and with different skin colors will have with higher moistur e content. They also more inclined to whitening function products. High portions of the target market for Retro Skincare products are in urban areas with the population that desire to buy skincare products. Our main target geographic area will be KILL and Clangor because both states hold the largest number of men also have more urban areas.So our geographically targeted location to market our skincare product is in Bangs, KILL Central, Wants Major, Cubans and Among. We analyses, and came up with a conclusion that these areas will be best place to promote and market our Retro Skincare products. 6. 3. Competitors The skin care market is very broad. It includes products labeled as body cream, shower cream, cleanser, moisturizer, day cream, after shave and etc. Our market positioning will be in the lower price quadrant of high quality natural products.While there are other companies that distribute variety of skin care products, there are no main business in Malaysia focuses exclusively on the men's skin care product market as Retro Skincare. This will provide considerable flexibility in pricing and allow for the creation of great deal of customer awareness and brand loyalty, erecting significant barriers to entry for potential competitors. However there are some businesses offering men's skincare products as minor part of their businesses. Our primary competitors for men skincare products are: 7. L'Oreal Paris 8. Grainier 9. Naive 10.Clean 11. Their shortcoming is that they contain more chemicals than the natural herbs and ingredients of our company Retro Skincare products. Our main wholesale competitors will be power retailers who merge the specialty store concept with the discount store's emphasis on price. These retail warehouses are large stores with products displayed on metal racks in a warehouse setting. There are two distinct types of retail warehouses, the first being a membership and the second a consumer store which is open to the general public. Their shortcoming as with other competitors is service.Buyers must travel to them to pick up their goods. Some of the power retailers have Just begun to offer delivery services, which is helping retailers to appreciate the value of using a distributor like our company Retro Skincare. 7. Competitive Forces, Strategies and Risk Assessment 7. 1. Competitive Forces There are 5 competitive forces as following and the weak and strong determine how strong each of the competitive forces in our business is: Large amount of capital required High retaliation possible from existing companies, if new entrants would bring innovative products and ideas to the industry.Therefore we are introducing groundbreaking product 2. Supplier power (Weak): Supplier located in another state Saba. They are not currently available for wholesale distribution in Slang Valley The supplier supply in larger scale Products are widely accessible Supplier do not pose any threat of forward integration There are many suppliers who can supply different brand of skincare products 3.Buyer power (Strong): There are many skin care products buyers: urban area professionals, skin problematic customers Most of the buyers are individuals that buy one brand of product and can bargain for lower prices Buyers tend to switch to another brand of skincare product or to start using it Buyers can easily choose different skincare reduces based on their skin need Buyers are price and benefit sensitive and their decision is often based on how much does a product will cost them with a benefit of it 4.Threat of Substitutes (Weak): There are many alternative types of skincare products, such as soap, traditional products (aloe Vera) Substitutes can rarely offer the same convenience Alternative types of skincare products almost always cost less and sometimes are more natural and less chemical 5.Competitive Rivalry (Very Strong): Moderate number of competitors If a firm would decide to leave an industry it would incur huge losses , so most of the mime it either bankrupts or stays in skincare industry for the lifetime Industry is very large but matured Size of competing firm's vary but they usually compete for different consumer segments Customers are loyal to their brands 7. 2. Strategies for competitive advantage Cost Leadership We will improve our business cost to lower than our competitor to sell our skincare products. We have lowest cost of delivery service, cost of staff and staff wages and other.Differentiation We offer and selling only one brand of skincare product. This makes us easier and convenient for us to promote and sell it. Only full service distribution company in skincare market around Slang Valley. Our products are male oriented, which harder to get in market We has strategic location of distributing store Retro skincare products has beautiful design for exterior packaging and promotions Brightening serum for male is unique Operational Effectiveness full delivery service in 24 hour of avail ability We had implemented good leadership to our staff in order to became successful distributing company in future.The combined experience of the principal owners brings upper office management skills, high levels of customer service, and over 20 years in distribution and sales management. Customer Orientation Individualized customer service – providing our customers with what they want, when and how they want it. Free samples of new product for the customers Lower cost with quality product Fully integrated programs to help customers increase sales through menu development, creative promotions, advertising, and custom marketing material.Key personnel will stay in contact with our customers, and will be able to respond to changes in this market much faster than our competitors. 7. 3. Risk Assessments We had analyses that of strategic to sell our skincare product for male is good cause it has less competitor and the market is growing slowly. Risk from loses will be reduced if our company product sale is increased. Moreover we have good better promotion strategic without reducing our product sale profits.Based on our current analysis we find out that we has medium or lower than medium risk levels to sell our product in Slang Valley area. 8. Product 8. 1 . Description and Concepts The brand name is â€Å"Skinner†. The products are natural with less use of chemicals. The products will be delivered to customers or retailers in overnight shipping, on-site revive and 24- hour availability after the purchase is made. Our underlying rationality in choosing products is to select outlines that bring reliable quality, competitive prices and product satisfaction to our customers. We have personally quality we ensure.The primary products to be distributed through Retro Skincare will be as the following with the price stated: All the products are came in gig except shampoo and conditioner will be 100 ml. 8. 2. Features and Advantages Other service provided for customer and retailers: Free delivery, customer service ND consultation Retro Skincare will make these same products which available through wholesale sellers available through our excellent, full delivery service by sending these products directly to their doorstep at a competitive price Orders in bulk will be sold for customer carryout or delivery.Easy to use because the directions are written on each of the product itself and small template is provided to let customers know the benefit of these products and how to use it. These products are offered according to men's different skin type and they can choose to buy the product according to their skin need. For example there are 3 types of cleanser offered by Retro Skincare: Acne free, sensitive skin and Hydra Energetic. All the creams can last long for 2 months of usage.

Mutagen

Quantification of a Mutagen: Tobacco By Selenia Lopez November 30, 2012 Section 44 Abstract: Tobacco is commonly used and kills millions until this day. Tobacco is a potential mutagen due to all the chemicals added. The spot overlay Ames test was conducted to test at what concentration of tobacco was it at the most mutagenic. The hypothesis of this experiment was as the concentration of tobacco increases, the growth of bacteria increases. The control for this experiment had a UV positive and a UV negative. Four different tobacco concentrations, Salmonella Typhimurium of strain 1538 were incubated for 24-72 hours to observe bacterial growth.At a 100% bacterial growth was at its greatest number of colonization and at 5% the mutagen was at its least. These results reflected that tobacco has the ability to grow without histidine making it a mutagen and at which concentration was it the most mutagenic. Intro: A mutagen is a substance which increases the frequency of mutation in a plant or animal population, which can lead to a variety of consequences or alterations in the DNA structure (Ligorio, Izzotti, Pulliero, Arrigo 2011). Salmonella being a mutagen can cause mutations such as substitution, insertion, deletion and frame shift depending on the strain.S. typhimurium carries a defective gene making it unable to synthesize histidine from its culture medium. Some types of mutations can be reversed with the gene regaining its function. Tobacco having lots of chemicals with possibility of being mutagenic is known to kill an estimated six million people worldwide each year and drains $500 billion annually. It can be consumed as a pesticide and in the form of nicotine tartrate. It is sometimes used in some medicines, but most commonly used as a drug. The use of Ames test is based on the assumption that any substance that is mutagenic. For this eason the FDA uses the Ames test to screen many chemicals to measures the mutagenic strength in bacterial cells (FDA 2012). In t his experiment to test whether tobacco is mutagenic and if so at what concentration has the greatest bacterial growth. The spot overlay Ames test was conducted. Though it’s a cheap version of the Ames test, the result were still compatible. The hypothesis of this experiment was as the concentration of tobacco increases, the growth increases. The greatest growth should occur in the 100% concentration and the least in the 5% concentration. Methods and materials:The control for the experiment was an Agar plate that had a UV positive reactant with a known mutagen, and UV negative reactant that hasn’t been reactant with anything. With a micro pipette that amounted to 250ul, strain TA 1538 of Salmonella was Obtained and placed on to the Agar plate and spread with a sterilized rod. The four paper discs that have been soaked in the 5%, 25%, 50%, and 100% of tobacco concentration were placed spaced apart on the plate. The plate was sealed and place it in the incubator at 37 deg ree for 24-72 hours. Results: Table 1: The table shows the concentration of mutagens to the number of colonies observed.Concentrations | Colonies | 100% | 39 | 50% | 13 | 25% | 8 | 5% | 2 | The control resulted in the UV positive having growth and the UV negative having none at all. At a 100% bacterial growth was at its greatest number of colonization at 39. At 5% the mutagen was at its least with only 2 colonies. Discussion: The mutagenic effect of the chemical has caused many bacteria to regain the ability to grow without histidine in tobacco, causing the formation of the colonies seen around the disc (Pounikar and Dawande 2010). Not only is a tobacco a mutagen, but colony growth increased as the concentration increased.The hypothesis was supported according to the data show in the table. Even though the disc were slightly shifted. The numbers were still attainable. The 100% concentration had the highest bacterial colonization and the 5% concentration had the least as predicted. I n future experiments, more trials can be done. In order to make sure the results will remain the same every time; or using other mutagens to see how they react in the 100% concentration. This type of experiment can also be useful in finding out whether smoking tobacco or chewing tobacco is more mutagenic or if the different brands make a difference on how mutagenic they can be.Works Cited Asiatic Journal of Biotechnology Resources: Pounikar, R and Dawande, A. Y. (2010). Detection of potential carcinogens by Ames test. Doi: 01: 57-64. Department of Health Sciences: Ligorion M, Izzotti A, Pulliero A, and Arrigo P. (2011) Mutagens interfere with microRNA maturation by inhibiting DICER. An in silico biology analysis. Doi: 10. 1016 www. FDA. gov: Li Y, Yan J, Bishop M, Jones MY, Watanabe F, Biris AS, Rice P, Zhou T, Chen T. (2011) Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay. Mutagen Quantification of a Mutagen: Tobacco By Selenia Lopez November 30, 2012 Section 44 Abstract: Tobacco is commonly used and kills millions until this day. Tobacco is a potential mutagen due to all the chemicals added. The spot overlay Ames test was conducted to test at what concentration of tobacco was it at the most mutagenic. The hypothesis of this experiment was as the concentration of tobacco increases, the growth of bacteria increases. The control for this experiment had a UV positive and a UV negative. Four different tobacco concentrations, Salmonella Typhimurium of strain 1538 were incubated for 24-72 hours to observe bacterial growth.At a 100% bacterial growth was at its greatest number of colonization and at 5% the mutagen was at its least. These results reflected that tobacco has the ability to grow without histidine making it a mutagen and at which concentration was it the most mutagenic. Intro: A mutagen is a substance which increases the frequency of mutation in a plant or animal population, which can lead to a variety of consequences or alterations in the DNA structure (Ligorio, Izzotti, Pulliero, Arrigo 2011). Salmonella being a mutagen can cause mutations such as substitution, insertion, deletion and frame shift depending on the strain.S. typhimurium carries a defective gene making it unable to synthesize histidine from its culture medium. Some types of mutations can be reversed with the gene regaining its function. Tobacco having lots of chemicals with possibility of being mutagenic is known to kill an estimated six million people worldwide each year and drains $500 billion annually. It can be consumed as a pesticide and in the form of nicotine tartrate. It is sometimes used in some medicines, but most commonly used as a drug. The use of Ames test is based on the assumption that any substance that is mutagenic. For this eason the FDA uses the Ames test to screen many chemicals to measures the mutagenic strength in bacterial cells (FDA 2012). In t his experiment to test whether tobacco is mutagenic and if so at what concentration has the greatest bacterial growth. The spot overlay Ames test was conducted. Though it’s a cheap version of the Ames test, the result were still compatible. The hypothesis of this experiment was as the concentration of tobacco increases, the growth increases. The greatest growth should occur in the 100% concentration and the least in the 5% concentration. Methods and materials:The control for the experiment was an Agar plate that had a UV positive reactant with a known mutagen, and UV negative reactant that hasn’t been reactant with anything. With a micro pipette that amounted to 250ul, strain TA 1538 of Salmonella was Obtained and placed on to the Agar plate and spread with a sterilized rod. The four paper discs that have been soaked in the 5%, 25%, 50%, and 100% of tobacco concentration were placed spaced apart on the plate. The plate was sealed and place it in the incubator at 37 deg ree for 24-72 hours. Results: Table 1: The table shows the concentration of mutagens to the number of colonies observed.Concentrations | Colonies | 100% | 39 | 50% | 13 | 25% | 8 | 5% | 2 | The control resulted in the UV positive having growth and the UV negative having none at all. At a 100% bacterial growth was at its greatest number of colonization at 39. At 5% the mutagen was at its least with only 2 colonies. Discussion: The mutagenic effect of the chemical has caused many bacteria to regain the ability to grow without histidine in tobacco, causing the formation of the colonies seen around the disc (Pounikar and Dawande 2010). Not only is a tobacco a mutagen, but colony growth increased as the concentration increased.The hypothesis was supported according to the data show in the table. Even though the disc were slightly shifted. The numbers were still attainable. The 100% concentration had the highest bacterial colonization and the 5% concentration had the least as predicted. I n future experiments, more trials can be done. In order to make sure the results will remain the same every time; or using other mutagens to see how they react in the 100% concentration. This type of experiment can also be useful in finding out whether smoking tobacco or chewing tobacco is more mutagenic or if the different brands make a difference on how mutagenic they can be.Works Cited Asiatic Journal of Biotechnology Resources: Pounikar, R and Dawande, A. Y. (2010). Detection of potential carcinogens by Ames test. Doi: 01: 57-64. Department of Health Sciences: Ligorion M, Izzotti A, Pulliero A, and Arrigo P. (2011) Mutagens interfere with microRNA maturation by inhibiting DICER. An in silico biology analysis. Doi: 10. 1016 www. FDA. gov: Li Y, Yan J, Bishop M, Jones MY, Watanabe F, Biris AS, Rice P, Zhou T, Chen T. (2011) Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay.